Introduction : Excessive or irregular uterine bleeding is a frequently encountered problem in gynaecology practice. A need has been felt for a safe . simple and reliable method for sampling the endometrium. Aims And Objectives : The study was undertaken to study the efficacy of aspiration cytology for endometrial sampling by karman's canula with that of endometrlal biopsy obtained by dilatation and curettage. Material And Method : The study was conducted in the Dept.of Obst.and Gynae. S.M.S. Medical College,Jaipur(Raj.).100 peri and postmenopausal women with complaints of abnormal uterine bleeding without organic pathology were included.