Objectives: To evaluate the patients for cervical epithelial abnormalities by Pap Smear cytology and HPV DNA testing by PCR, to compare the efficacy of Pap Smear cytology and HPV DNA PCR for detection of CIN and to correlate histopathology report of colposcopic directed cervical biopsy with cytological findings and HPV positivity. Methods : Fifty patients in the age group 21-45 years presenting with unhealthy cervices were subjected to a detailed work- up comprising of Pap Smear cytology. HPV DNA PCR testing of cervical secretions and colposcopic directed biopsy (where indicated). Results : In the present study, the prevalence of HPV infection was 14%.