All India Congress of Obstetrics & Gynaecology, 04–08 Jan 2009 · Birla Auditorium, Jaipur

Background: Misoprostol is the drug of choice for medical abortion worldwide but consensus is yet to be reached regarding its preferred route of administration. Aims: To compare the outcome of sublingual with vaginal administrations of misoprostol for induction of second trimester abortion. Methods: A randomised comparative trial where 300 women at 1320 weeks gestation, requiring medical abortion, were randomly assigned to sublingual or vaginal route for misoprostol administration with a dose schedule of 400 ìg three hourly, up to a maximum five doses over 24 h. The same doses were repeated for another 24 h in non-responders.