Objective(s) : To compare effectiveness of two dosing regimens of intravaginal misoprostol for second trimester termination of pregnancy. Method(s) : This was a prospective study of 100 pregnant women requiring legal termination of 2 nd trimester of pregnancy between 13 to 20 wks. They were randomised in two groups and two regimens of misoprostol intravaginally were used as - Group 1 (50) : 600 ~tg of misoprostol stat followed by 400 ~tg every 8 hourly and Group 11 (50) : 400 ug of misoprostol every 6 hourly upto maximum of 48 hours. Statistical analysis were performed using appropriate statistical test.