Objectives: To compare the effectiveness of sublingual misoprostol 400pg versus intramuscular oxytocin 101U for prevention of postpartum blood loss. Methods: Study design: Double blind randomized controlled trial. Data Collection: From pregnant women in labor admitted to labor room in teaching hospital attached to J. N. Medical College, Belgaum. Sample Size: 652 (actual enrolled 672) Randomization: Computer generated randomization list with block size of two. Intervention: One group received 4OOpg misoprostol powder (two 200pg powdered tablets) sublingually and 2ml placebo IM injection, while other group received placebo powder sublingually, and 2ml IM Inj.