Objective: To compare the efficacy of two injections of high dose intravenous iron for prophylaxis of iron deficiency anemia in pregnancy as compared to daily oral iron supplementation. Method: A total of 30 pregnant women with a singleton pregnancy and hemoglobin more than 10 g% at 16-24 weeks gestation were identified and randomly divided into two groups. Group A was started on daily oral iron therapy of 100 mg of elemental iron. Group B was given 250 mg of iron sorbitol intravenous and repeated at an interval of 4-6 weeks. Blood indices were evaluated at the beginning of study and at 36 weeks to gee the effect after iron supplementation in the two groups.