Background : Post partum haemorrhage is a leading cause of direct maternal deaths, accounting to 30% deaths in India. Two-thirds of cases occur in women without any predisposing factors. Preventing third stage haemorrhage during caesarean section can bring down the associated morbidity and mortality. Aim: To assess the third stage blood loss during caesarean section with the use of Misoprostol, to assess it's efficacy, adverse drug reactions and effect on perinatal outcome. Material and Methods : 200 low risk term caesarean sect' ons were included in the study from January to August 2008 in GMCH, Aurangabad.