Objective : To analyze the outcome of three different regimens in treatment of non specific vaginitis on outpatient basis. Methods : Sixty non-pregnant women presenting with chief complaint of vaginal discharge per vaginum or diagnosed to have vaginosis on clinical examination were reruited in study over 8 month period from February 2008- October 2008.Treatment was divided into three groups. Group I: 150mg oral fluconazole, 1 gm oral azithromycin, 2 gm oral secnidazole to both partners + Clotrimazole vaginal pessary 100mg per vaginum (PV) x 6 days. Group II: 150 mg oral fluconazole, 2 gm secnidazole to both partners + Clotrimazole vaginal pessary 100mg PV x 6 days.