We present two cases of Caudal regression syndrome. One of which presented in the second trimester with USG showing absent lower limb. The second case was a 35 year old G3 P2 LI NNDl with 35 weeks of gestational age with previous LSCS with overt diabetes on insulin with breech presentation came for routine antenatal checkup. P/A: Uterus was overdistended, polyhydramnios was present. Breech presentation. FH good. USG showed 36 weeks gestation with lumbosacral dysgenesis. Sacral agenesis is a part of caudal regression syndrome, which is a wide spectrum of disorders which may present from early pregnancy to term. This condition is not always associated with maternal diabetes.