Objective : To study the efficacy of early administration of vaginal misoprostol (24 hours after oral mifeprislone) for medical termination of pregnancy in <63 days of gestation and compare this with efficacy with standard protocol of mifepristone misoprostol combination at 48 hours interval. Methods : Eligible women as cases were given mifepristone 200 mg orally followed by vaginal misoprostol 400 ^ig at 24 hours interval and controls were given mifepristone 200 mg orally followed by vaginal misoprostol 400 u.g at 48 hours interval. Ail participants were called for follow up pelvic ultrasound scan within 14 days.