1st International Conference on Recent Advances in Anaesthesiology (INCRAA - 2009), 30 Jan – 01 Feb 2009 · Nehru Auditorium, AIIMS New Delhi

Genetic epidemiologic studies suggest a strong genetic influence on the outcome from sepsis, and genetics may explain the wide variation in the individual response to infection. Several candidate genes have been identified as important in the inflammatory response. Polymorphisms affecting Toll-like receptor (TLR); Tumor necrosis factor (TNF)- and TNF-ß genes, interleukin (IL)-1 receptor antagonist gene, the heat shock protein gene, the IL-6 gene, the IL-10 gene, the CD-14 gene mediated responses could predispose to excessive inflammation during an infection and contribute to an increased risk for poor outcomes in patients with sepsis.