Objective : To assess and comparatively evaluate the safety and efficacy of sublingual and per rectal misoprostol and intravenous methyl ergometrine in active management of third stage of labour. Method and materials : Study was conducted in the department of Obstetrics and Gynaecology, Pt JNM medical college, Raipur, CG from Jan06 to July 06 over 300 selected cases in labour divided in three groups of 100 each., in group I cases were given 400 microgram sublingually, in group II were given 600 ng per rectally and group, group III methyl ergometrine were given 0.2mg i/v at the time of delivery of anterior shoulder of the fetus.