Objectives : To study trend of some of the major RTIs and STIs and their determinants in women attending gynecological OPD at a tertiary referral centre, association between clinical presentation and laboratory results and the associated risk factors. Methods : This was a cross-sectional study conducted from October 2006- April 2008 on 412 women in reproductive age group i.e. 15-49 years who attended gynecological OPD at Safdarjung Hospital, New Delhi. Diagnosis of various RTIs/STIs was made separately on basis of symptoms, clinical examination and laboratory investigations and their sensitivity and specificity compared taking laboratory diagnosis as gold standard.